Study on the efficacy of ceftriaxone versus azithromycin for the treatment of uncomplicated enteric fever among the patients admitted in a tertiary level hospital

Background: Typhoid fever is a severe debilitating and potentially life threating illness. In Bangladesh, typhoid fever is a round the year problem which sometimes take epidemic proportions. The reasons behind such occurrences are unsafe water supply, defective sewage system and unhygienic food handling practice. This study aimed to compare the efficacy of ceftriaxone and azithromycin in the treatment of uncomplicated enteric fever.Methods: An observational study was conducted at the department of pharmacology in Dhaka medical college, Dhaka, Bangladesh. Data were collected from blood culture positive patients for Salmonella typhi and Salmonella paratyphi, who admitted in the Dhaka medical college and hospital, Dhaka during the period of July 2015 to June 2016. Data was collected by using a structured questioner, face to face interview, physical examination and investigation reports. Patients were hospitalized during the entire treatment period and at admission evaluation was made by history and physical examination in a structured format. Subjects ware asked regarding changes in symptoms and possible adverse effects of the study drugs. All patients were asked to return two weeks after completion of treatment for follow up. Blood culture of Salmonella typhi or Salmonella paratyphi were done in all cases. Total 91 patients were culture positive for either S. typhi or S. paratyphi which were finally studied.Results: During the study period out of 91 patients, 51 were receiving ceftriaxone and 40 were receiving azithromycin. Clinical cure was achieved in 46 patients (90%) of ceftriaxone group and in 31 patients (78%) in the azithromycin group. There were no significant differences of clinical cure between both treatment groups (p>0.05). Mean fever clearance time in ceftriaxone group was 3±1.4 days and was 4±1.6 days for azithromycin group. Difference in fever clearance time was statistically significant (p<0.05). No clinical relapses were detected in any study subject. No major side effects of both drugs occurred in any subject.Conclusions: These results indicated that both ceftriaxone and azithromycin were effective against enteric fever caused by sensitive organisms and multi drug resistant S. typhi and S. paratyphi. It is concluded that ceftriaxone is more effective and can be a convenient alternative for the treatment of enteric fever, especially in developing countries like us where medical resources are scarce

Development that works, March 31, 2011

This repository item contains a single issue of the Pardee Conference Series, On March 31, 2011, more than 100 people participated in a conference titled “Development That Works,” sponsored by Boston University’s Frederick S. Pardee Center for the Study of the Longer-Range Future in collaboration with the BU Global Development program. In the pages that follow, four essays written by Boston University graduate students capture the salient points and overarching themes from the four sessions, each of which featured presentations by outstanding scholars and practitioners working in the field of development. The conference agenda and speakers’ biographies are included following the essays.The theme and the title of the conference—”Development That Works”—stemmed from the conference organizers’ desire to explore, from a groundlevel perspective, what programs, policies, and practices have been shown—or appear to have the potential—to achieve sustained, long-term advances in development in various parts of the world. The intent was not to simply showcase “success stories,” but rather to explore the larger concepts and opportunities that have resulted in development that is meaningful and sustainable over time. The presentations and discussions focused on critical assessments of why and how some programs take hold, and what can be learned from them. From the influence of global economic structures to innovative private sector programs and the need to evaluate development programs at the “granular” level, the expert panelists provided well-informed and often provocative perspectives on what is and isn’t working in development programs today, and what could work better in the future

Making the great transformation, November 13, 14, and 15, 2003

This repository item contains a single issue of the Pardee Conference Series, a publication series that began publishing in 2006 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future. This Conference took place during November 13, 14, and 15, 2003. Co-organized by Cutler Cleveland and Adil Najam.The conference discussants and participants analyze why transitions happen, and why they matter. Transitions are those wide-ranging changes in human organization and well being that can be convincingly attributed to a concerted set of choices that make the world that was significantly and recognizably different from the world that becomes. Transition scholars argue that that history does not just stumble along a pre-determined path, but that human ingenuity and entrepreneurship have the ability to fundamentally alter its direction. However, our ability to ‘will’ such transitions remains in doubt. These doubts cannot be removed until we have a better understanding of how transitions work

Steady Free Convection Boundary Layer Flows at a Vertical Plate with Variable Fluid Properties

This paper investigates the similarity solutions of the steady two-dimensional flow of a stream of viscous fluid with far field viscosity past a vertical plate. The variable viscosity, thermal conductivity and heat sink in momentum and energy equations are incorporated. The governing system of equations are transformed into dimensionless equations and solved numerically by using Maple-13 software for different boundary conditions and for various values of parameters. The effects of different values of physical parameters on the velocity and temperature profiles as well as on the skin-friction coefficient and Nusselt number are discussed

Advanced Modulation Scheme of a Dual-Active-Bridge Series Resonant Converter (DABSRC) for Enhanced Performance

This paper proposes a two-degree-of-freedom (2-DoF) modulation technique for the efficient optimization of an open-loop three-phase dual-active-bridge series resonant converter (3P-DABSRC). The efficiency and performance of an conventional dual-active-bridge (DAB) converter decrease when it is operated over a wide range of voltage gain. The efficiency and performance of a DAB converter depend upon the switching and conduction losses. Circulating current is the main cause of conduction loss, and hard switching of active switches adds a switching loss. To increase the performance of DAB converters, the first objective is to minimize the conduction loss, and the second objective is to reduce the switching loss. Still, unfortunately, it is not easy to achieve these two objectives simultaneously. Circulating current helps us to reduce the switching loss, but the unbridled amount of circulating current will increase the root-mean-square inductor tank current, and as a result, the conduction loss will be increased. This paper presents an advanced modulation scheme for a 3P-DABSRC that can be used not only in low-power applications, but also in high-power applications. The DABSRC consists of a series LC resonant tank, isolated high-frequency transformer, and dual active bridge connected with the primary and secondary sides of the transformer. The proposed 2-DoF modulation technique not only minimizes the circulating current, but also eliminates the switching loss. Keeping the minimum phase shift between the primary and secondary bridges reduces the circulating current, and thus, all switches can be operated with zero-voltage switching (ZVS) for the entire power range. The power is controlled by changing the switching frequency from 45 to 63 kHz. To confirm the proposed topology and modulation scheme, a 1500 W DABSRC, which interfaces a 300 V DC bus with a 75 V DC bus, is simulated. A loss model of the proposed topology is also made to verify the results. The simulation results are used to confirm the proper operation of the 3P-DABSRC

Advanced Modulation Scheme of a Dual-Active-Bridge Series Resonant Converter (DABSRC) for Enhanced Performance

This paper proposes a two-degree-of-freedom (2-DoF) modulation technique for the efficient optimization of an open-loop three-phase dual-active-bridge series resonant converter (3P-DABSRC). The efficiency and performance of an conventional dual-active-bridge (DAB) converter decrease when it is operated over a wide range of voltage gain. The efficiency and performance of a DAB converter depend upon the switching and conduction losses. Circulating current is the main cause of conduction loss, and hard switching of active switches adds a switching loss. To increase the performance of DAB converters, the first objective is to minimize the conduction loss, and the second objective is to reduce the switching loss. Still, unfortunately, it is not easy to achieve these two objectives simultaneously. Circulating current helps us to reduce the switching loss, but the unbridled amount of circulating current will increase the root-mean-square inductor tank current, and as a result, the conduction loss will be increased. This paper presents an advanced modulation scheme for a 3P-DABSRC that can be used not only in low-power applications, but also in high-power applications. The DABSRC consists of a series LC resonant tank, isolated high-frequency transformer, and dual active bridge connected with the primary and secondary sides of the transformer. The proposed 2-DoF modulation technique not only minimizes the circulating current, but also eliminates the switching loss. Keeping the minimum phase shift between the primary and secondary bridges reduces the circulating current, and thus, all switches can be operated with zero-voltage switching (ZVS) for the entire power range. The power is controlled by changing the switching frequency from 45 to 63 kHz. To confirm the proposed topology and modulation scheme, a 1500 W DABSRC, which interfaces a 300 V DC bus with a 75 V DC bus, is simulated. A loss model of the proposed topology is also made to verify the results. The simulation results are used to confirm the proper operation of the 3P-DABSRC